Mitochondrial Peptide
MOTS-c Research Peptide
As of 2026-08-23, DMV Research lists MOTS-c (CAS 1456083-98-9) and publishes 1 third-party certificate of analysis for it, for laboratory research use only.
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino-acid peptide encoded in the mitochondrial 12S ribosomal RNA and secreted from mitochondria. It is supplied as a lyophilized powder for laboratory research applications.
For laboratory research use only. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, cosmetic, or dietary supplement.
Compound identity
- Name
- MOTS-c
- Class
- Mitochondrial Peptide
- CAS number
- 1456083-98-9
- Molecular formula
- C17H28N8O13
- Also known as
- Mitochondrial Open Reading Frame of the 12S rRNA-c, Mitochondrial-derived peptide
- Sequence
- MRWQEMGYIFYPRKLR
Research context
MOTS-c (CAS 1456083-98-9) is a mitochondrial-derived peptide (MDP) encoded within the small subunit of the mitochondrial ribosome. Unlike nuclear-encoded peptides, it is translated from a non-canonical open reading frame in the 12S rRNA gene. As a research reagent it is studied in cell biology systems examining mitochondrial signaling.
The scientific literature on MOTS-c has examined its behavior in in-vitro and preclinical laboratory models in the context of mitochondrial function and cellular energy metabolism research. It is not approved for human therapeutic use by the FDA or any equivalent regulatory agency.
DMV Research supplies MOTS-c with a per-batch third-party Certificate of Analysis confirming identity and purity for research use.
Related research
MOTS-c is profiled alongside DMV Research's other mitochondrial peptide overviews, including AOD-9604, HGH Fragment 176-191, PEG-MGF, hGH C-Terminal Fragments — AOD-9604 & HGH Fragment 176-191 Research Hub, Retatrutide, Semaglutide, and Tirzepatide — each with its own identity data, cited literature, and FAQ. See the product listing for current pricing and the MOTS-c Certificate of Analysis for lab-verified purity data.
Frequently asked questions
What is MOTS-c?+
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome's 12S rRNA gene. It is classified as a mitochondrial-derived peptide (MDP) and used as a research reference compound. CAS 1456083-98-9.
How is MOTS-c different from nuclear-encoded peptides?+
MOTS-c is encoded by the mitochondrial genome, not nuclear DNA, which makes it structurally unique among endogenous peptides. Its sequence (MRWQEMGYIFYPRKLR) is derived from a non-canonical ORF in the 12S ribosomal RNA.
Is MOTS-c approved for human use?+
No. MOTS-c is not approved for human use by any regulatory agency. As supplied by DMV Research it is for laboratory and research purposes only.
What purity is the MOTS-c research peptide?+
Each batch is independently tested to 99%+ purity by third-party laboratories, with a Certificate of Analysis available per batch.
Research use only
All products are intended for laboratory and research use only (RUO) and are not for human consumption, ingestion, or any in-vivo use.
The statements on this page have not been evaluated by the FDA. For laboratory research use only. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, cosmetic, or dietary supplement.