MOTS-C
As of 2026-06-08, DMV Research publishes 1 third-party certificate of analysis for MOTS-C (CAS 1627580-64-6), for laboratory research use only.
Mitochondrial-derived peptide for metabolic and exercise research.
For laboratory research use only. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, cosmetic, or dietary supplement.
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For in-vitro and pre-clinical research use only. Not for human consumption, therapeutic use, or veterinary application. Research Use Only Policy
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Certificate of Analysis Report
Third-party HPLC purity testing for this compound. Download the full-resolution reports below.
Independently HPLC-tested for identity, purity, and concentration.
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Compound Information
Updated 2026-06-08Technical specifications
A 16-amino-acid mitochondrially-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. One of several MDPs studied as metabolic-signaling molecules with AMPK-pathway activity in cellular-biology research.
What Is MOTS-C?
- Type
- Mitochondrially-Derived Peptide
- CAS Number
- 1627580-64-6
- Molecular Weight
- 2,174.6 g/mol
- Molecular Formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Amino Acids
- 16
- Sequence
- MRWQEMGYIFYPRKLR
- Primary Target
- AMPK, FOXO1, ARE (antioxidant response element)
Stability Information
Lyophilized (powder)
-20°C· stable
Reconstituted
2–8°C· use within 30 days
AMPK Activation Pathway
Exercise-mimetic mitochondrial signaling
Research Outcomes
Sources & References
7 sources · research references
Cell Metabolism
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
2015
Lee C, Zeng J, Drew BG, et al.
Aging Cell
Mitochondrial Genotype Associated with Exceptional Longevity in MOTS-c Coding Region
2015
Fuku N, Pareja-Galeano H, Zempo H, et al.
Nature Communications
MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis
2021
Reynolds JC, et al.
Frontiers in Endocrinology
MOTS-c: A Promising Mitochondrial-Derived Peptide for Therapeutic Exploitation
2023
Zheng Y, Wei Z, Wang T
Diabetes and Metabolism Journal
Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
2022
Yoon TK, Lee CH, Kwon O, Kim MS
Journal of Translational Medicine
Mitochondria-Derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging
2023
Wan W, et al.
PubChem Database
MOTS-C Compound Information
Not for human consumption. This product is sold exclusively for research and educational purposes. For laboratory research use only. Not for human or veterinary use. Not for diagnostic or therapeutic use. Not a drug, food, cosmetic, or dietary supplement.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations. See our Research Use Only policy.
